To best ensure successful completion of large-scale research projects and the appropriate adoption of technologies that arise from their projects, investigators working in global health must pay attention not only to science, but to the ethical, social, and cultural issues that surround their work. These ethical, social, and cultural concerns have become increasingly important to the success of projects ＿＿（6）＿＿ in the developing world, including many of the projects funded by Grand Challenges in Global Health. ＿＿（7）＿＿ Grand Challenges in Global Health investigators, Drs. Singer and Lavery and their colleagues are providing advisory services on ethical, social, and cultural issues related to research in the developing world. In addition, their project aims to help foster the successful and appropriate adoption by communities ＿＿（8）＿＿ technologies that result from Grand Challenges in Global Health projects. The project team’s advisory service for Grand Challenges investigators is in place, and work has begun to plan for the successful adoption of technologies that may ＿＿（9）＿＿ from Grand Challenges in Global Health projects. The project team is currently conducting two global case studies, one on community engagement in research in the developing world and ＿＿（10）＿＿ on commercialization of health products in low-resource settings. The case studies will identify good practices in both areas.