A community-based study, Framingham Heart Study (FHS), was launched in 1948 in Framingham, Massachusetts, to analyze patterns of cardiovascular and other diseases. The original cohort consisted of 5,209 men and women between the ages of 30 and 62. The research has continued for 75 years and now includes second and third generations of participants. The MRIs were conducted between 1999 and 2019 with FHS participants born during the 1930s through the 1970s. The brain study consisted of 3,226 participants (53% female, 47% male) with an average age of about 57 at the time of the MRI. The research led by UC Davis compared the MRIs of people born in the 1930s to those born in the 1970s. It found gradual but consistent increases in several brain structures. For example, a measure that looked at brain volume (intracranial volume) showed steady increases decade by decade. For participants born in the 1930s, the average volume was 1,234 milliliters, but for those born in the 1970s, the volume was 1,321 milliliters, or about 6.6% greater volume. Cortical surface area—a measure of the brain’s surface— showed an even greater increase decade by decade. Participants born in the 1970s had an average surface area of 2,104 square centimeters compared to 2,056 square centimeters for participants born in the 1930s — almost a 15% increase in volume. The researchers found brain structures such as white matter, gray matter and hippocampus (a brain region involved in learning and memory) also increased in size when comparing participants born in the 1930s to those born in the 1970s. According to the Alzheimer’s Association, approximately 7 million Americans are currently living with Alzheimer’s disease. That number is expected to rise to 11.2 million by 2040. Although the numbers are rising with America’s aging population, the incidence of Alzheimer’s—the percentage of the population affected by the disease—is decreasing. A previous study found a 20 percent reduction in the incidence of dementia per decade since the 1970s. Improved brain health and size may be one reason why. “Larger brain structures like those observed in our study may reflect improved brain development and improved brain health,” DeCarli said. “A larger brain structure represents a larger brain reserve and may buffer the late-life effects of age-related brain diseases like Alzheimer’s and related dementias.”