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病人接受CHOP的處方治療,如下:
CHOP Regimen
Pre-medication
Dexamethasone 10 mg IV infusion 5 min, 15 min before C/T
Metoclopramide 10 mg IV over 15 min, 30 min before C/T, then 10 mg IV q6h × 1 day
Granisetron 2 mg PO, 60 min before C/T
Chemotherapy
Cyclophosphamide 750 mg/m $^{2}$ IV slowly push 3-5 min on day 1; then Doxorubicin 40 mg/m $^{2}$ IV slowly push 3-5 min on day 1; then Vincristine 1.4 mg/m $^{2}$ IV slowly push on day 1 (max. 2 mg); then Prednisolone 40 mg/m $^{2}$ /day PO bid × 5 days
Allopurinol 100 mg PO tid x 5 days started on day before chemotherapy
Cumulative dose of doxorubicin after this chemotherapy: 64 mg/m $^{2}$
依序回答下列三題。
處方中記錄doxorubicin的累積劑量是考量其何種毒性?
A心臟毒性正確答案
B骨髓毒性
C膀胱毒性
D血管外滲毒性
答案與詳解
