病人接受CHOP的處方治療,如下:
CHOP Regimen
Pre-medication
Dexamethasone 10 mg IV infusion 5 min, 15 min before C/T
Metoclopramide 10 mg IV over 15 min, 30 min before C/T, then 10 mg IV q6h × 1 day
Granisetron 2 mg PO, 60 min before C/T
Chemotherapy
Cyclophosphamide 750 mg/m $^{2}$ IV slowly push 3-5 min on day 1; then Doxorubicin 40 mg/m $^{2}$ IV slowly push 3-5 min on day 1; then Vincristine 1.4 mg/m $^{2}$ IV slowly push on day 1 (max. 2 mg); then Prednisolone 40 mg/m $^{2}$ /day PO bid × 5 days
Allopurinol 100 mg PO tid x 5 days started on day before chemotherapy
Cumulative dose of doxorubicin after this chemotherapy: 64 mg/m $^{2}$
依序回答下列三題。
CHOP處方中何者血管外滲(extravasation)會造成嚴重傷害?
Acyclophosphamide
Bdexamethasone
Cmetoclopramide
Dvincristine正確答案
答案與詳解
D
正確答案
Vincristine 屬於發疱劑(vesicant),外滲會造成嚴重組織壞死,是 CHOP 中外滲傷害最強者。